<![CDATA[Race Against Mind: An Alzheimer's Prevention Investigation]]>Race Against Mind is an Alzheimer's prevention investigation hosted by Sarah Kuhn, a double APOE4 carrier with a family history of early-onset Alzheimer's disease. Instead of waiting, Sarah started asking a different question: what does the research actually say, and what happens when you take it seriously?

Each episode goes deep on one piece of the prevention puzzle: exercise, sleep, metabolic health, alcohol, hormones. Sarah breaks down the science, examines how strong it really is, and shares what she did with that information in her own life. What worked, what didn't, and what she changed her mind about along the way.

If you carry APOE4, have a family history of Alzheimer's, or simply refuse to leave your brain health to chance, this show is for you.

]]>https://riverside.comRiverside.fm (https://riverside.com)Fri, 08 May 2026 18:24:19 GMTThu, 23 Apr 2026 22:18:31 GMT60Sarah Kuhn<p>Race Against Mind is an Alzheimer's prevention investigation hosted by Sarah Kuhn, a double APOE4 carrier with a family history of early-onset Alzheimer's disease. Instead of waiting, Sarah started asking a different question: what does the research actually say, and what happens when you take it seriously?</p><p></p><p>Each episode goes deep on one piece of the prevention puzzle: exercise, sleep, metabolic health, alcohol, hormones. Sarah breaks down the science, examines how strong it really is, and shares what she did with that information in her own life. What worked, what didn't, and what she changed her mind about along the way.</p><p></p><p>If you carry APOE4, have a family history of Alzheimer's, or simply refuse to leave your brain health to chance, this show is for you.</p>serialSarah Kuhnsfixkuhn@gmail.comno<![CDATA[The Exercise Research Every APOE4 Carrier Needs to Hear]]>This episode goes deep on the exercise pillar. The four mechanisms connecting movement to brain health, including a 2026 UCSF study that identified a liver enzyme that repairs the blood-brain barrier and what it reveals about why consistency matters at a molecular level.

We also get into why getting stronger is different from lifting consistently, what the SMART trial found when it measured both strength and aerobic capacity in the same participants, and why VO2 max may be the most important fitness number you are not tracking.

Plus my parents as a natural experiment, where my own protocol stands after two years of deliberate changes, and four questions to audit whether what you are already doing is actually building what your brain needs.

The research. The mechanisms. What I changed. What the data showed.

Show Notes

]]>21c844ae-2535-4659-9b1e-16f98a34177fFri, 01 May 2026 15:00:00 GMT<p>This episode goes deep on the exercise pillar. The four mechanisms connecting movement to brain health, including a 2026 UCSF study that identified a liver enzyme that repairs the blood-brain barrier and what it reveals about why consistency matters at a molecular level.</p><p>We also get into why getting stronger is different from lifting consistently, what the SMART trial found when it measured both strength and aerobic capacity in the same participants, and why VO2 max may be the most important fitness number you are not tracking.</p><p></p><p>Plus my parents as a natural experiment, where my own protocol stands after two years of deliberate changes, and four questions to audit whether what you are already doing is actually building what your brain needs.</p><p></p><p>The research. The mechanisms. What I changed. What the data showed.</p><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/exercise-research-every-apoe4-carrier" target="_blank">Show Notes</a></p>no00:22:2113The Exercise Research Every APOE4 Carrier Needs to Hearfull<![CDATA[How to Build a Baseline and Understand Your Risk]]>For APOE4 carriers, knowing your risk is only useful if you know what to do with it. In this episode, Sarah walks through her path to developing a baseline, and discusses the labs that actually matter, fasting insulin, homocysteine, hs-CRP, Vitamin D etc. Sarah also discusses why standard functional medicine isn't specific enough for APOE4 biology, and how to interpret baseline data without losing your mind in the process.

Whats in this episode:

  • What APOE4 actually is, and what it isn't
  • Why the "nothing you can do" frame is the most expensive mistake APOE4 carriers can make
  • The research caveat problem: why so many studies don't apply to people like me
  • How I built my first baseline with blood work and cognitive testing before changing anything
  • Why I started with Parsley Health and then moved to Dale Bredesen's PreCODE program
  • What my PreCODE report revealed across metabolic, inflammatory, and cognitive domains
  • Why my cognitive scores required more context than just a number on a page (ADHD, breastfeeding, medication status)
  • Three practical takeaways for anyone at the beginning of this journey
  • Why exercise leads Season 1, even though it wasn't where I started

Show Notes & References

]]>582c0788-2b1f-4742-a834-80006a246418Sat, 25 Apr 2026 19:44:14 GMT<p>For APOE4 carriers, knowing your risk is only useful if you know what to do with it. In this episode, Sarah walks through her path to developing a baseline, and discusses the labs that actually matter, fasting insulin, homocysteine, hs-CRP, Vitamin D etc. Sarah also discusses why standard functional medicine isn't specific enough for APOE4 biology, and how to interpret baseline data without losing your mind in the process.</p><p></p><p>Whats in this episode: </p><ul><li>What APOE4 actually is, and what it isn't</li><li>Why the "nothing you can do" frame is the most expensive mistake APOE4 carriers can make</li><li>The research caveat problem: why so many studies don't apply to people like me</li><li>How I built my first baseline with blood work and cognitive testing before changing anything</li><li>Why I started with Parsley Health and then moved to Dale Bredesen's PreCODE program</li><li>What my PreCODE report revealed across metabolic, inflammatory, and cognitive domains</li><li>Why my cognitive scores required more context than just a number on a page (ADHD, breastfeeding, medication status)</li><li>Three practical takeaways for anyone at the beginning of this journey</li><li>Why exercise leads Season 1, even though it wasn't where I started</li></ul><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/understanding-my-risk" target="_blank">Show Notes &amp; References</a></p>no00:15:1712How to Build a Baseline and Understand Your Riskfull<![CDATA[APOE4 Positive and Alzheimer's Risk: One Woman's 5-Year Brain Health Protocol ]]>Sarah is homozygous APOE4, the highest genetic risk profile for Alzheimer's disease. Her grandmother had it. Her mother was diagnosed at 58. When she got her own results, she didn't wait.

In this first episode, she traces how a family legacy of Alzheimer's became a five-year personal research project and why the window for meaningful intervention is decades earlier than most people think. She breaks down what carrying two copies of APOE4 actually means, where the science is solid and where it falls short, and how she built a protocol around the pillars most likely to move the needle: nutrition, sleep, fitness, alcohol, and hormones. This is where it all starts.

Show Notes & References

]]>67a2d928-9b1a-4fc2-9bc6-cec842d9e6e3Sat, 25 Apr 2026 19:40:51 GMT<p>Sarah is homozygous APOE4, the highest genetic risk profile for Alzheimer's disease. Her grandmother had it. Her mother was diagnosed at 58. When she got her own results, she didn't wait.</p><p></p><p>In this first episode, she traces how a family legacy of Alzheimer's became a five-year personal research project and why the window for meaningful intervention is decades earlier than most people think. She breaks down what carrying two copies of APOE4 actually means, where the science is solid and where it falls short, and how she built a protocol around the pillars most likely to move the needle: nutrition, sleep, fitness, alcohol, and hormones. This is where it all starts.</p><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/why-i-started-this-podcast" target="_blank">Show Notes &amp; References</a></p>no00:21:2011APOE4 Positive and Alzheimer's Risk: One Woman's 5-Year Brain Health Protocol full