<![CDATA[The Evidence Brief]]>There is a gap between what the research says and what the internet tells you. The Evidence Brief exists to close it.


Julian Douwes, M.D. is Chief Medical Officer of a German hospital and works in functional medicine, chronic infectiology, Lyme disease, neuroscience and neuromodulation. Every week he takes one topic from longevity, brain health, chronic infections, peptides or functional medicine and walks through what the evidence actually shows: strong, moderate, emerging, limited or preclinical. Experimental protocols are taken seriously. Nothing is treated as risk free. No miracle claims, no dismissals, no sponsor-shaped opinions.


Most episodes are solo. When a topic needs a specialist, a researcher or a clinician joins to put it in its proper light.


The show is education, not medical advice. Nothing here replaces the conversation you need to have with your own physician.


Written companion: the weekly Evidence Brief newsletter and 230+ referenced articles at juliandouwes.com.

]]>https://juliandouwes.comRiverside.fm (https://riverside.com)Sat, 14 Nov 2026 00:39:11 GMTThu, 12 Nov 2026 12:56:06 GMT60Dr. med. univ. Julian Douwes<p>There is a gap between what the research says and what the internet tells you. The Evidence Brief exists to close it.</p><p><br /></p><p>Julian Douwes, M.D. is Chief Medical Officer of a German hospital and works in functional medicine, chronic infectiology, Lyme disease, neuroscience and neuromodulation. Every week he takes one topic from longevity, brain health, chronic infections, peptides or functional medicine and walks through what the evidence actually shows: strong, moderate, emerging, limited or preclinical. Experimental protocols are taken seriously. Nothing is treated as risk free. No miracle claims, no dismissals, no sponsor-shaped opinions.</p><p><br /></p><p>Most episodes are solo. When a topic needs a specialist, a researcher or a clinician joins to put it in its proper light.</p><p><br /></p><p>The show is education, not medical advice. Nothing here replaces the conversation you need to have with your own physician.</p><p><br /></p><p>Written companion: the weekly Evidence Brief newsletter and 230+ referenced articles at juliandouwes.com.</p>episodicDr. med. univ. Julian Douwesjulian.douwes@st-george-hospital.comno<![CDATA[E01 - What is fasting actually doing?]]>E01 - What is fasting actually doing?


What changes when we stop eating: the amount, the timing, or the cellular response? Dr. Julian Douwes follows fasting biology, human feeding experiments and a surprising mouse lifespan study to help you decide what an eating window is meant to achieve.


Download the FAST checklist (PDF)

https://manybot-files.s3.eu-central-1.amazonaws.com/fb5944608/ca/2026/11/12/c8695c33f11c6e55d7fcb533e585e143/FAST.pdf


Chapters

00:00 The Evidence Brief - introduction

00:14 The three fasting questions

01:09 Fuel and cellular signals

03:38 Measuring autophagy

05:28 Changing dinner

06:21 Weight-stable experiment

09:11 The daily clock

10:28 A year of weight loss

13:28 Actual animal lifespan

15:12 Human aging measures

16:09 Choose a question

19:44 Answers and FAST resource

21:31 Closing note


Studies and further reading

Sutton2018: https://pmc.ncbi.nlm.nih.gov/articles/PMC5990470/

Liu2022: https://pubmed.ncbi.nlm.nih.gov/35443107/

DiFrancesco2024: https://pmc.ncbi.nlm.nih.gov/articles/PMC11485257/

Bensalem2025: https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP287938

Vujovic2022: https://pubmed.ncbi.nlm.nih.gov/36198293/

CALERIE: https://pmc.ncbi.nlm.nih.gov/articles/PMC10148951/

Insulin physiology: https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance

Fasting safety: https://pmc.ncbi.nlm.nih.gov/articles/PMC6521152/


The Evidence Brief is an educational program. It does not provide medical advice, diagnosis or treatment and does not create a physician-patient relationship. Some therapies discussed are investigational or used off-label. Discuss any change to your care with your own physician. Impressum and privacy policy: https://juliandouwes.com/impressum


]]>https://juliandouwes.coma5211fc8-3360-4ebc-a53e-2133ee22caaeThu, 12 Nov 2026 12:59:51 GMT<p>E01 - What is fasting actually doing?</p><p><br /></p><p>What changes when we stop eating: the amount, the timing, or the cellular response? Dr. Julian Douwes follows fasting biology, human feeding experiments and a surprising mouse lifespan study to help you decide what an eating window is meant to achieve.</p><p><br /></p><p>Download the FAST checklist (PDF)</p><p><a href="https://manybot-files.s3.eu-central-1.amazonaws.com/fb5944608/ca/2026/11/12/c8695c33f11c6e55d7fcb533e585e143/FAST.pdf" rel="noopener noreferrer nofollow">https://manybot-files.s3.eu-central-1.amazonaws.com/fb5944608/ca/2026/11/12/c8695c33f11c6e55d7fcb533e585e143/FAST.pdf</a></p><p><br /></p><p>Chapters</p><p>00:00 The Evidence Brief - introduction</p><p>00:14 The three fasting questions</p><p>01:09 Fuel and cellular signals</p><p>03:38 Measuring autophagy</p><p>05:28 Changing dinner</p><p>06:21 Weight-stable experiment</p><p>09:11 The daily clock</p><p>10:28 A year of weight loss</p><p>13:28 Actual animal lifespan</p><p>15:12 Human aging measures</p><p>16:09 Choose a question</p><p>19:44 Answers and FAST resource</p><p>21:31 Closing note</p><p><br /></p><p>Studies and further reading</p><p>Sutton2018: <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5990470/" rel="noopener noreferrer nofollow">https://pmc.ncbi.nlm.nih.gov/articles/PMC5990470/</a></p><p>Liu2022: <a href="https://pubmed.ncbi.nlm.nih.gov/35443107/" rel="noopener noreferrer nofollow">https://pubmed.ncbi.nlm.nih.gov/35443107/</a></p><p>DiFrancesco2024: <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11485257/" rel="noopener noreferrer nofollow">https://pmc.ncbi.nlm.nih.gov/articles/PMC11485257/</a></p><p>Bensalem2025: <a href="https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP287938" rel="noopener noreferrer nofollow">https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP287938</a></p><p>Vujovic2022: <a href="https://pubmed.ncbi.nlm.nih.gov/36198293/" rel="noopener noreferrer nofollow">https://pubmed.ncbi.nlm.nih.gov/36198293/</a></p><p>CALERIE: <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10148951/" rel="noopener noreferrer nofollow">https://pmc.ncbi.nlm.nih.gov/articles/PMC10148951/</a></p><p>Insulin physiology: <a href="https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance" rel="noopener noreferrer nofollow">https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance</a></p><p>Fasting safety: <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6521152/" rel="noopener noreferrer nofollow">https://pmc.ncbi.nlm.nih.gov/articles/PMC6521152/</a></p><p><br /></p><p>The Evidence Brief is an educational program. It does not provide medical advice, diagnosis or treatment and does not create a physician-patient relationship. Some therapies discussed are investigational or used off-label. Discuss any change to your care with your own physician. Impressum and privacy policy: <a href="https://juliandouwes.com/impressum" rel="noopener noreferrer nofollow">https://juliandouwes.com/impressum</a></p><p><br /></p>no00:21:4111E01 - What is fasting actually doing?full