<![CDATA[Grey Zone Longevity]]>Are you fully healthy, or are your cells in the Grey Zone between health and disease? GZL explores the latest longevity science to uncover what we can do now to detect risk earlier, restore resilience, and move aging cells back towards optimal health.

Hosted by pharma scientist Jon Brudvig, PhD, and longevity physician Grant Fraser, MD, the show features conversations with scientists, physicians, biotech founders, and leaders in prevention and aging biology. GZL examines the interventions, biomarkers, drugs, lifestyle strategies, and emerging ideas that help us extend healthspan and change how we think about healthy aging.

]]>https://grantfrasermd.com/Riverside.fm (https://riverside.com)Sat, 18 Jul 2026 03:39:27 GMTFri, 01 May 2026 21:23:23 GMT60Jon Brudvig and Grant Fraser<p>Are you fully healthy, or are your cells in the Grey Zone between health and disease? GZL explores the latest longevity science to uncover what we can do now to detect risk earlier, restore resilience, and move aging cells back towards optimal health.<br /></p><p>Hosted by pharma scientist Jon Brudvig, PhD, and longevity physician Grant Fraser, MD, the show features conversations with scientists, physicians, biotech founders, and leaders in prevention and aging biology. GZL examines the interventions, biomarkers, drugs, lifestyle strategies, and emerging ideas that help us extend healthspan and change how we think about healthy aging.</p>episodicJon Brudvig and Grant Fraserjjbrudvig@gmail.comyes<![CDATA[Immune Aging with Natalia Mitin, PhD]]>Can You Measure Immune Aging? Natalia Mitin on Immune Resilience, Senescence, and Personalized Longevity

In this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Natalia Mitin, co-founder and CEO of Sapere Bio, to explore one of longevity medicine’s biggest blind spots: how do we measure immune function and immune aging in an individual—and use that information to make better decisions?

From immune resilience, T-cell exhaustion, and cellular senescence to thymic regeneration, fisetin, rapamycin, GLP-1 drugs, exercise, and gut health, this conversation examines what it will take to move beyond population averages and toward truly personalized longevity medicine.

In this episode

  • Why immune health is better understood as balanced or unbalanced—not simply strong or weak
  • How immune resilience may relate to infection, chronic disease, healthspan, and longevity
  • What happens to the thymus and T cells as we age
  • The promise and unanswered questions surrounding TRIIM and thymic regeneration
  • How SapereX measures immune resilience and cellular senescence
  • What the evidence says about fisetin, rapamycin, GLP-1 drugs, exercise, and other interventions
  • Why measuring first may be wiser than blindly expanding a longevity stack

About Dr. Natalia Mitin

Natalia Mitin, PhD, is the co-founder and CEO of Sapere Bio. Her work focuses on cellular senescence, immune aging, and biomarkers designed to evaluate immune resilience and monitor how it changes over time.

Research discussed

Follow the hosts

]]>b1214467-81ad-4412-bb44-9027c981496aFri, 17 Jul 2026 16:04:48 GMT<h1>Can You Measure Immune Aging? Natalia Mitin on Immune Resilience, Senescence, and Personalized Longevity</h1><p>In this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Natalia Mitin, co-founder and CEO of Sapere Bio, to explore one of longevity medicine’s biggest blind spots: how do we measure immune function and immune aging in an individual—and use that information to make better decisions?</p><p>From immune resilience, T-cell exhaustion, and cellular senescence to thymic regeneration, fisetin, rapamycin, GLP-1 drugs, exercise, and gut health, this conversation examines what it will take to move beyond population averages and toward truly personalized longevity medicine.</p><h2>In this episode</h2><ul><li>Why immune health is better understood as balanced or unbalanced—not simply strong or weak</li><li>How immune resilience may relate to infection, chronic disease, healthspan, and longevity</li><li>What happens to the thymus and T cells as we age</li><li>The promise and unanswered questions surrounding TRIIM and thymic regeneration</li><li>How SapereX measures immune resilience and cellular senescence</li><li>What the evidence says about fisetin, rapamycin, GLP-1 drugs, exercise, and other interventions</li><li>Why measuring first may be wiser than blindly expanding a longevity stack</li></ul><h2>About Dr. Natalia Mitin</h2><p>Natalia Mitin, PhD, is the co-founder and CEO of Sapere Bio. Her work focuses on cellular senescence, immune aging, and biomarkers designed to evaluate immune resilience and monitor how it changes over time.</p><ul><li><a rel="noopener noreferrer nofollow" href="https://www.saperex.com/saperex-longevity" target="_blank">SapereX Longevity testing</a></li><li><a rel="noopener noreferrer nofollow" href="https://www.saperex.com/" target="_blank">Sapere Bio</a></li><li><a rel="noopener noreferrer nofollow" href="https://www.linkedin.com/in/nataliamitin" target="_blank">Natalia Mitin on LinkedIn</a></li></ul><h2>Research discussed</h2><ul><li><a rel="noopener noreferrer nofollow" href="https://www.nature.com/articles/s41467-023-38238-6" target="_blank">Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection</a></li><li><a rel="noopener noreferrer nofollow" href="https://pubmed.ncbi.nlm.nih.gov/37693401/" target="_blank">Profiling an integrated network of cellular senescence and immune resilience measures in natural aging</a></li><li><a rel="noopener noreferrer nofollow" href="https://www.nature.com/articles/s41586-026-10242-y" target="_blank">Thymic health consequences in adults</a></li><li><a rel="noopener noreferrer nofollow" href="https://www.nature.com/articles/s41586-026-10243-x" target="_blank">Thymic health and immunotherapy outcomes in patients with cancer</a></li><li><a rel="noopener noreferrer nofollow" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6826138/" target="_blank">Reversal of epigenetic aging and immunosenescent trends in humans—the TRIIM trial</a></li><li><a rel="noopener noreferrer nofollow" href="https://clinicaltrials.gov/study/NCT04375657" target="_blank">TRIIM-X clinical-trial registration</a></li><li><a rel="noopener noreferrer nofollow" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6197652/" target="_blank">Fisetin is a senotherapeutic that extends health and lifespan</a></li></ul><h2>Follow the hosts</h2><ul><li><a rel="noopener noreferrer nofollow" href="https://jonbrudvig.substack.com/" target="_blank">Jon Brudvig, PhD — Translation on Substack</a></li><li><a rel="noopener noreferrer nofollow" href="https://www.grantfrasermd.com/" target="_blank">Grant Fraser, MD — Longevity and Precision Medicine</a></li></ul><p></p>no01:21:4012Immune Aging with Natalia Mitin, PhDfull<![CDATA[Diet & Lifestyle Factors with Gary E. Fraser, MBChB, PhD]]>Are the biggest longevity gains hiding in plain sight?

In this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Gary Fraser, a pioneering epidemiologist behind the Adventist Health Studies, to explore what decades of human data reveal about diet, lifestyle, disease risk, and lifespan. From plant-based diets and nuts to exercise, body weight, dairy, fish, and processed foods, this conversation cuts through the noise to ask a simple question: what actually seems to help people live longer, healthier lives?

]]>1a0db9ee-4a7c-4ba2-b93b-0f10ad3861caFri, 01 May 2026 21:29:06 GMT<p>Are the biggest longevity gains hiding in plain sight?</p><p>In this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Gary Fraser, a pioneering epidemiologist behind the Adventist Health Studies, to explore what decades of human data reveal about diet, lifestyle, disease risk, and lifespan. From plant-based diets and nuts to exercise, body weight, dairy, fish, and processed foods, this conversation cuts through the noise to ask a simple question: what actually seems to help people live longer, healthier lives?</p>no01:06:2511Diet & Lifestyle Factors with Gary E. Fraser, MBChB, PhDfull